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INS — NOX4

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by PTP1B: NOX4 (NOX4) → Insulin Receptor/Insulin complex (INSR-INS) (modification, activates)
  Mahadev et al., Mol Cell Biol 2004*
  Evidence: mutant phenotype, assay, other species

Text-mined interactions from Literome

Oldenborg et al., Inflamm Res 1999 (Diabetes Mellitus) : These results suggest that elevated levels of insulin do not affect the NADPH-oxidase activity but, together with superoxide anions, interfere with myeloperoxidase availability and a subsequent myeloperoxidase dependent generation of reactive oxygen metabolites in fMet-Leu-Phe stimulated normal human neutrophils
Piatti et al., Circulation 2003 (Angina Pectoris...) : After insulin bolus, during saline, insulin induced NOx , endothelin-1, and forearm cGMP release was almost abolished ... ADMA levels were positively correlated with basal endothelin-1 levels and negatively correlated with insulin induced incremental levels of NOx and forearm cGMP release
Hsieh et al., Am J Hypertens 2004 (Hyperinsulinism...) : Insulin infusion significantly increased MAP and NOx ( sum of nitrate and nitrite ) levels after 90 min and thereafter the elevated MAP and NOx responses were sustained throughout the study
Kobayashi et al., Hypertension 2004 (Diabetes Mellitus, Experimental...) : Although in our model the ACh induced relaxation and NOx- ( NO2-+NO3- ) /cGMP production were unchanged, the clonidine induced and insulin induced relaxations and NOx-/cGMP production were all greatly attenuated
Yang et al., Am J Hypertens 2005 : Insulin stimulated NAD ( P ) H oxidase activity increases migration of cultured vascular smooth muscle cells
Fortuño et al., Diabetes 2006 (Atherosclerosis...) : Insulin stimulated NADPH oxidase activity ; this effect was abolished by a specific protein kinase C inhibitor
Yang et al., Am J Hypertens 2006 : The aim of this study was to determine the mechanism of insulin stimulated NAD ( P ) H oxidase activity ... Neither wortmannin nor pertussis toxin, which inhibit insulin stimulated NAD ( P ) H oxidase activity in other cell types, affected insulin or insulin plus Ang II-stimulated O ( 2 ) ( - ) production ... Insulin stimulates NAD ( P ) H oxidase activity and with Ang II synergistically stimulates it in cultured rat VSMC by increasing the NADH/NAD ( + ) redox potential, but not by phosphatidylinositol 3-kinase or heterotrimeric G ( iota ) protein dependent pathways
Wei et al., J Biol Chem 2006 : Angiotensin II-induced NADPH oxidase activation impairs insulin signaling in skeletal muscle cells
Yang et al., Atherosclerosis 2008 : It is concluded that insulin in the presence of NO stimulates cGMP which stimulates PP-2A activity causing inhibition of autonomous CaM kinase II activity and thus VSMC migration, and that insulin in the presence of Ang II inhibits PP-2A and stimulates autonomous CaM kinase II activities by a NAD ( P ) H oxidase dependent mechanism which are associated with insulin stimulated NAD ( P ) H oxidase dependent migration
Bourgoin et al., Am J Physiol Heart Circ Physiol 2008 (Body Weight...) : Furthermore, the HFHS diet induced a reduced insulin stimulated glucose transport activity in muscles and increased levels of NAD ( P ) H oxidase protein and nitrotyrosine formation in vascular tissues
Schröder et al., Arterioscler Thromb Vasc Biol 2009 : The expression of Nox1 and Nox4 was increased during insulin induced differentiation, and insulin increased ROS production
San José et al., Free Radic Biol Med 2009 : Insulin induced NADPH oxidase activation promotes proliferation and matrix metalloproteinase activation in monocytes/macrophages ... Insulin mediated NADPH oxidase activation stimulated MMP-9 activation in monocytes and cell proliferation in macrophages
Fortuño et al., Hypertension 2009 (Hypertension) : EXP3179, but not losartan and EXP3174, dose-dependently inhibited ( P < 0.05 ) phorbol myristate acetate and insulin stimulated NADPH oxidase activity
Crutzen et al., Pflugers Arch 2012 : NOX inhibitors such as DPI and plumbagin nearly totally inhibited insulin release provoked by exposure of the BRIN-BD11 cells to a hypotonic medium
Rebelato et al., Life Sci 2012 : Inhibition of NADPH oxidase activity impaired glucose metabolism and glucose stimulated insulin secretion
Yan et al., Journal of the American Heart Association 2012 (Diabetes Mellitus, Experimental...) : Insulin increased Nox4 expression, oxidant stress, and adipocyte differentiation in WT MSCs, and these insulin induced effects were reversed by Nox4 siRNA ( P < 0.05 ; n=6 )