Gene interactions and pathways from curated databases and text-mining

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MAPK6 — NPPA

Text-mined interactions from Literome

Pandey et al., Biochem Biophys Res Commun 2000 : We have examined the effect of atrial natriuretic peptide (ANP) and its guanylyl cyclase/natriuretic peptide receptor-A (NPRA) on mitogen activated protein kinase/extracellular signal regulated kinase 2 ( MAPK/ERK2 ) activity in rat mesangial cells overexpressing NPRA ... ANP inhibited agonist stimulated activity of MAPK/ERK2 by 65-75 % in cells overexpressing NPRA, whereas in vector transfected cells, its inhibitory effect was only 18-20 % ... NPRA antagonist A71915 and KT5823, a specific inhibitor of cGMP dependent protein kinase ( PKG ) completely reversed the inhibitory effect of ANP on MAPK/ERK2 activity
Kiemer et al., World J Gastroenterol 2002 (Ischemia...) : Since ANP has recently been shown to be a regulator of the p38 MAPK pathway in endothelial cells ( Kiemer et al. Circ Res 2002, 90 : 874-881 ), aim of this study was to investigate activities of MAPK during ischemia and reperfusion and effects of ANP on MAPK
Hayashi et al., Biochem Biophys Res Commun 2004 (Cardiomegaly) : To determine how ANP inhibits cardiomyocyte hypertrophy, we examined the mechanism of ANP induced suppression of the MAPK activation
Zhang et al., J Mol Endocrinol 2005 : The results revealed that ANP could inhibited FSH induced pig oocyte maturation and cumulus expansion and prevent the full phosphorylation of mitogen activated protein kinase in both oocytes and cumulus cells, and that these inhibitory effects could be mimicked by 8-Br-cyclic guanosine 5'-monophosphate ( 8-Br-cGMP ), but blocked by a protein kinase G ( PKG ) inhibitor KT5823
Anand-Srivastava et al., Peptides 2005 : Furthermore, the activation of NPR-C receptor by C-ANP ( 4-23 ) and CNP inhibits the mitogen activated protein kinase activity stimulated by endothelin-3, platelet derived growth factor, phorbol-12 myristate 13-acetate, suggesting that NPR-C receptor might also be coupled to other signal transduction system or that there may be an interaction of the NPR-C receptor and some other signaling pathways
Keller et al., World J Gastroenterol 2005 (Reperfusion Injury) : Hepatocyte cytoskeleton during ischemia and reperfusion -- influence of ANP mediated p38 MAPK activation ... This study reveals that ANP mediated p38 MAPK activation leads to changes in hepatocyte cytoskeleton involving an elevation of phosphorylated Hsp27 and thereby for the first time shows functional consequences of ANP induced hepatic p38 MAPK activation
Kilić et al., J Mol Cell Cardiol 2009 (Cardiomegaly) : Treatment with 1 pM 17beta-estradiol for 24 h increased cell size ( females : 20 %, P < 0.05 ; males : 29 %, P < 0.05 ) and ANP expression ( females : 414 %, P < 0.05 ; males : 497 %, P < 0.05 ) in a NHE-1-, and ERK1/2 MAPK dependent manner
Sugimoto et al., J Biol Chem 1996 : In order to understand the mechanism of the anti-proliferative effect of ANP, we examined whether ANP could inhibit MAPK by inducing MKP-1 in cultured rat glomerular mesangial cells ... The protein expression of MKP-1 was maximally stimulated by ANP at 120 min. Treatment of the cells with ANP for 120 min resulted in an inhibition of phorbol ester induced activation of MAPK , while the activation of MEK was not affected by ANP
Haneda et al., Kidney Int 1996 : Interestingly, atrial natriuretic peptide (ANP) partially inhibited PDBu induced activation of MAPK and MAPKK
Anand-Srivastava et al., J Hypertens 1997 (Hypertension) : The activation of ANP-C receptor by C-ANP ( 4-23 ) ( a ring deleted peptide of ANP ) and C-type natriuretic peptide inhibits the mitogen activated protein kinase activity stimulated by endothelin-3, platelet derived growth factor and phorbol-12 myristate 13-acetate