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MAPK3 — NRAS
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAPK3
→
NRAS
(increases, NRAS Activity)
Evidence: Expression of N17Ras attenuated activation of ERK (Figure 4A) and JNK (Figure 4B). In contrast, selective activation of Ras was sufficient for ERK but not JNK activation.
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KEGG Axon guidance:
HRAS/KRAS/NRAS
→
MAPK1/MAPK3
(protein-protein, indirect effect)
-
KEGG Neurotrophin signaling pathway:
MAPK1/MAPK3
→
HRAS/KRAS/NRAS
(protein-protein, inhibition)
Text-mined interactions from Literome
Giehl et al., Oncogene 2000
(Pancreatic Neoplasms) :
Stimulation of cells with epidermal growth factor (EGF) or fetal calf serum ( FCS ) resulted in
activation of
N-Ras , but not K-Ras, as well as activation of c-Raf, MEK-1, and p42
MAPK
Whitwam et al., Oncogene 2007
(Cell Transformation, Neoplastic...) :
Although both
NRAS and KRAS
activate mitogen activated protein kinase signaling, only NRAS enhances MYC activity in these cells
Hamilton et al., Oncogene 1998
:
Ha-ras and
N-ras regulate
MAPK activity by distinct mechanisms in vivo