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GDNF — NTN3
Text-mined interactions from Literome
Saarma et al., Microsc Res Tech 1999
:
Like neurotrophins, GDNF family proteins are responsible for the development and maintenance of various sets of sensory and sympathetic neurons but, in addition,
GDNF and NTN are also
responsible for the development and survival of the enteric neurons, and
NTN for parasympathetic neurons
Akerud et al., J Neurochem 1999
(Nerve Degeneration) :
We therefore examined their function in ventral mesencephalon cultures and found that
NTN promoted survival comparable with GDNF, but only
GDNF induced sprouting and hypertrophy of developing dopaminergic neurons ...
NTN was found to be as potent as GDNF at preventing the death of nigral dopaminergic neurons, but only
GDNF induced tyrosine hydroxylase staining, sprouting, or hypertrophy of dopaminergic neurons
Harada et al., Neuroscience 2003
(Retinal Degeneration) :
Exogenous
GDNF increased brain derived neurotrophic factor, basic fibroblast growth factor and GDNF, but not
NTN mRNA production ... On the other hand,
NTN increased NTN, but not
GDNF mRNA production in cultured Müller cells