Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Gao et al., Hepatology 1999 : HGF alone induced moderate levels of c-Jun-N-terminal kinase (JNK) and p44/p42 mitogen activated protein kinase ( MAPK ), resulting in moderate levels of AP-1-DNA binding activity
Mendes et al., Nitric Oxide 2002 : Finally, the p42/44MAPK inhibitor, PD 98059, prevented IL-1 induced AP-1 activation in a concentration that did not inhibit iNOS expression
Darmoul et al., Am J Pathol 2003 (Colonic Neoplasms) : This effect was reversed by the MEK inhibitor PD98059 in consonance with the ability of thrombin or AP1 to induce phosphorylation of p42/p44 extracellular regulated protein kinases
Tu et al., Cardiovasc Toxicol 2003 : Distinct roles of p42/p44 ( ERK ) and p38 MAPK in oxidant induced AP-1 activation and cardiomyocyte hypertrophy
Fradette et al., Curr Drug Metab 2004 (Anoxia...) : The up-regulation of CYP3A6 implies a PTK- and p42/44MAPK dependent stabilization/activation, nuclear translocation of HIF-1 and AP-1 , binding to CYP3A6 promoter, and transactivation of the gene to induce CYP3A6 expression
Bisping et al., Clin Cancer Res 2009 (Multiple Myeloma...) : RTKI, bortezomib, and dexamethasone were active as single agents in t ( 4 ; 14 ) + MM. RTK inhibition triggered complementary proapoptotic pathways ( e.g., decrease of Mcl-1, down-regulation of p44/42 mitogen activated protein kinase, and activation of proapoptotic stress activated protein/c-Jun NH ( 2 ) -terminal kinases )
Li et al., ASN neuro 2012 (Demyelinating Diseases) : The activation of p42/p44 MAPK ( mitogen activated protein kinase ) and induction of the transcription factor c-Jun serve as negative regulators of myelination