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JUN — NUP43
Text-mined interactions from Literome
Gao et al., Hepatology 1999
:
HGF alone induced moderate levels of c-Jun-N-terminal kinase (JNK) and
p44/p42 mitogen activated protein kinase ( MAPK ), resulting in moderate
levels of
AP-1-DNA binding activity
Mendes et al., Nitric Oxide 2002
:
Finally, the
p42/44MAPK inhibitor, PD 98059,
prevented IL-1 induced
AP-1 activation in a concentration that did not inhibit iNOS expression
Darmoul et al., Am J Pathol 2003
(Colonic Neoplasms) :
This effect was reversed by the MEK inhibitor PD98059 in consonance with the ability of thrombin or
AP1 to
induce phosphorylation of
p42/p44 extracellular regulated protein kinases
Tu et al., Cardiovasc Toxicol 2003
:
Distinct
roles of
p42/p44 ( ERK ) and p38 MAPK in oxidant induced
AP-1 activation and cardiomyocyte hypertrophy
Fradette et al., Curr Drug Metab 2004
(Anoxia...) :
The up-regulation of CYP3A6 implies a PTK- and
p42/44MAPK dependent stabilization/activation, nuclear translocation of HIF-1 and
AP-1 , binding to CYP3A6 promoter, and transactivation of the gene to induce CYP3A6 expression
Bisping et al., Clin Cancer Res 2009
(Multiple Myeloma...) :
RTKI, bortezomib, and dexamethasone were active as single agents in t ( 4 ; 14 ) + MM. RTK inhibition triggered complementary proapoptotic pathways ( e.g., decrease of Mcl-1, down-regulation of
p44/42 mitogen activated protein kinase, and
activation of proapoptotic stress activated
protein/c-Jun NH ( 2 ) -terminal kinases )
Li et al., ASN neuro 2012
(Demyelinating Diseases) :
The activation of
p42/p44 MAPK ( mitogen activated protein kinase ) and
induction of the transcription factor
c-Jun serve as negative regulators of myelination