Gene interactions and pathways from curated databases and text-mining

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MYC — PCNA

Text-mined interactions from Literome

Warner et al., Mol Cell Biol 1999 : c-Myc causes a small increase in cyclin D levels, but this effect contributes little to the loss of TGF-beta responses in these cells
Neve et al., Oncogene 2000 (Breast Neoplasms...) : Ectopic expression of c-Myc led to an increase in D cyclin levels, CDK2 activity and resulted in a partial G1 rescue
Beier et al., EMBO J 2000 : Induction of cyclin E-cdk2 kinase activity, E2F dependent transcription and cell growth by Myc are genetically separable events
Deb-Basu et al., Cell cycle (Georgetown, Tex.) 2006 : We have found that cyclin dependent kinase 2 (CDK2) is required by MYC to induce apoptosis
Jansen-Dürr et al., Proc Natl Acad Sci U S A 1993 : Activation of cyclin A expression by MYC led to a growth factor independent association of cyclin A and cdk2 with the transcription factor E2F and correlated with an increase in E2F transcriptional activity
Pérez-Roger et al., Oncogene 1997 : Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27 ( Kip1 ) binding to newly formed complexes
Berns et al., Oncogene 1997 : Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity
Müller et al., Oncogene 1997 : Activation of Myc triggers a rapid induction of cyclin E/cdk2 kinase activity and degradation of p27