Teter et al., Infect Immun 2004
:
The catalytic A1 polypeptide of CT (CTA1) then crosses the ER membrane, enters the cytosol, ADP-ribosylates the stimulatory alpha subunit of the heterotrimeric G protein ( Gsalpha ) at the cytoplasmic face of the plasma membrane, and activates adenylate cyclase Caudle et al., BMC neuroscience 2007
(Hyperalgesia) :
The conjugate SP-CTA stimulates adenylate cyclase in cultured cells that are transfected with either the NK1 or NK2 receptor, but not the NK3 receptor