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NUP43 — PDGFB
Text-mined interactions from Literome
Cospedal et al., Cardiovasc Res 1999
:
While
PDGF-BB stimulation of FAK tyrosine phosphorylation is not
dependent on
p42/p44 MAP kinase activation, PDGF-BB and IGF-I both stimulate p42/p44 MAP kinase activity and the chemotactic response to these factors is partially dependent on MAP kinase activation
Hsu et al., Cell Signal 2001
(MAP Kinase Signaling System) :
Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed
p42/p44 mitogen activated protein kinase ( MAPK ) activation
induced by TNF-alpha and
PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response, indicating that Ras and Raf may be required for activation of these kinases
Cartel et al., Am J Physiol Lung Cell Mol Physiol 2001
(MAP Kinase Signaling System) :
PDGF-BB mediated activation of
p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylation ... Chemical inhibition of Janus kinase, phosphatidylinositol 3-kinase, Src kinase, or tyrosine phosphorylation inhibition of the PDGF beta-receptor ( PDGFR-beta ) did not abrogate
PDGF-BB induced
p42(MAPK) activation or its threonine or tyrosine phosphorylation ... A dominant negative cytoplasmic receptor for hyaluronan mediated motility variant 4 ( RHAMMv4 ), a regulator of MAPKK-MAPK interaction and activation, did not inhibit
PDGF-BB induced
p42(MAPK) activation nor did a construct expressing PDGFR-beta with cytoplasmic tyrosines mutated to phenylalanine ... These results suggest that
PDGF-BB mediated activation of
p42(MAPK) requires the PDGFR-beta but is independent of its tyrosine phosphorylation
Takenaka et al., J Cell Biochem 2004
:
PDGF-BB stimulated the phosphorylation of
p44/p42 mitogen activated protein ( MAP ) kinase, p38 MAP kinase, and stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) among the MAP kinase superfamily
Kannemeier et al., FASEB J 2004
(Arteriosclerosis) :
FSAP inhibited PDGF-BB binding to human VSMC and concomitantly blocked
PDGF-BB dependent phosphorylation of mitogen activated protein kinase
p42/p44 and tyrosine phosphorylation of other proteins