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PDGFRB — PIK3R1

Pathways - manually collected, often from reviews:

• KEGG Focal adhesion: EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• KEGG Pathways in cancer: PDGFRA/PDGFRB → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• KEGG Glioma: PDGFRA/PDGFRB → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• KEGG Glioma: PDGFRA/PDGFRB → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• KEGG Prostate cancer: EGFR/ERBB2/FGFR1/FGFR2/IGF1R/INSRR/PDGFRA/PDGFRB → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB) → PI3K Class I family (PIK3CA/PIK3R1/PIK3CB/PIK3R1/PIK3CG/PIK3R6) (modification, activates)
  Hooshmand-Rad et al., J Cell Sci 2000, Chaudhary et al., J Cell Biochem 2001, Burgering et al., Nature 1995, Kavanaugh et al., Biochemistry 1994, Roche et al., Proc Natl Acad Sci U S A 1994, Cooper et al., Mol Cell Biol 1993, Anderson et al., Curr Biol 1998
  Evidence: assay, physical interaction
• NCI Pathway Database Nectin adhesion pathway: PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Kanzaki et al., J Cell Sci 2008
  Evidence: mutant phenotype
• Reactome Reaction: PIK3R1 → PDGFRB (reaction) Fantl et al., Cell 1992, Coughlin et al., Science 1989, Heldin et al., Biochim Biophys Acta 1998
• Reactome Reaction: PIK3R1 → PDGFRB (indirect_complex) Fantl et al., Cell 1992, Coughlin et al., Science 1989, Heldin et al., Biochim Biophys Acta 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: PDGFRB — PIK3R1 McGlade et al., Mol Cell Biol 1992*, Larose et al., Oncogene 1993*, Larose et al., J Biol Chem 1995*
• IRef Bind Interaction: PDGFRB — PIK3R1 Panayotou et al., Mol Cell Biol 1993*
• IRef Bind_translation Interaction: PDGFRB — PIK3R1 (x-ray crystallography) Pauptit et al., Acta Crystallogr D Biol Crystallogr 2001*
• IRef Bind_translation Interaction: PDGFRB — PIK3R1 (surface plasmon resonance) Panayotou et al., Mol Cell Biol 1993*
• IRef Bind_translation Interaction: PDGFRB — PIK3R1 (affinity chromatography technology) McGlade et al., Mol Cell Biol 1992*, Larose et al., J Biol Chem 1995*
• IRef Bind_translation Interaction: PDGFRB — PIK3R1 (affinity chromatography technology) Larose et al., J Biol Chem 1995*
• IRef Bind_translation Interaction: PDGFRB — PIK3R1 (affinity chromatography technology) Larose et al., Oncogene 1993*, Larose et al., J Biol Chem 1995*
• IRef Bind_translation Interaction: PDGFRB — PIK3R1 (far western blotting) McGlade et al., Mol Cell Biol 1992*, Larose et al., J Biol Chem 1995*
• IRef Biogrid Interaction: PDGFRB — PIK3R1 (direct interaction, pull down) Ren et al., Mol Cell Biol 2005*
• IRef Biogrid Interaction: PDGFRB — PIK3R1 (physical association, affinity chromatography technology) Chamberlain et al., J Biol Chem 2004*
• IRef Biogrid Interaction: PDGFRB — PIK3R1 (physical association, affinity chromatography technology) Farooqui et al., Anticancer Res 1999*
• IRef Dip Interaction: PDGFRB — PIK3R1 (physical association, biophysical) Myers et al., Ann N Y Acad Sci 1995*
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Takahashi et al., EMBO J 2006
• IRef Hprd Interaction: PDGFRB — PIK3R1 (in vivo) Farooqui et al., Anticancer Res 1999*, McGlade et al., Mol Cell Biol 1992*
• IRef Intact Interaction: PDGFRB — PIK3R1 (association, surface plasmon resonance) Ladbury et al., Proc Natl Acad Sci U S A 1995*
• IRef Intact Interaction: PDGFRB — PIK3R1 (association, nuclear magnetic resonance) Shoelson et al., EMBO J 1993*
• IRef Intact Interaction: PDGFRB — PIK3R1 (association, cross-linking study) Williams et al., J Biol Chem 1993*
• IRef Intact Interaction: PDGFRB — PIK3R1 (association, nuclear magnetic resonance) Breeze et al., EMBO J 1996*
• IRef Intact Interaction: PDGFRB — PIK3R1 (association, isothermal titration calorimetry) O'Brien et al., Protein Sci 2000*
• IRef Intact Interaction: PDGFRB — PIK3R1 (association, biophysical) Panayotou et al., EMBO J 1992*
• IRef Intact Interaction: PDGFRB — PIK3R1 (association, coimmunoprecipitation) Kashishian et al., EMBO J 1992*
• IRef Intact Interaction: PDGFRB — PIK3R1 (association, coimmunoprecipitation) Saucier et al., Oncogene 2002*
• IRef Intact Interaction: PDGFRB — PIK3R1 (association, pull down) Nishimura et al., Mol Cell Biol 1993*
• IRef Intact Interaction: PDGFRB — PIK3R1 (association, classical fluorescence spectroscopy) Panayotou et al., EMBO J 1992*
• IRef Intact Interaction: PDGFRB — PIK3R1 (association, pull down) Gay et al., Biochemistry 1997*
• IRef Intact Interaction: PDGFRB — PIK3R1 (physical association, two hybrid) Park et al., Mol Cells 2001*
• IRef Intact Interaction: PDGFRB — PIK3R1 (association, circular dichroism) Panayotou et al., EMBO J 1992*
• IRef Intact Interaction: PDGFRB — PIK3R1 (association, pull down) Ramalingam et al., Bioorg Med Chem 1995*
• IRef Ophid Interaction: PDGFRB — PIK3R1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Mahon et al., Cell Signal 2005 : Thus, A-Raf can regulate PLCgamma1 signalling via a PDGFR dependent mechanism and may also regulate PI3K signalling via a PDGFR independent mechanism
Mellgren et al., Circ Res 2008 : Our data demonstrate that PDGFRbeta is required for the formation of 2 distinct cVSMC populations and that loss of PDGFRbeta-PI3K signaling disrupts epicardial cell migration
Zheng et al., J Biol Chem 2009 : The anti-proliferative effects of Klf4 on neointimal formation depend largely on PDGFR mediated PI3K signaling without involvement of the RAR alpha activated signaling pathways
Kazlauskas et al., EMBO J 1990 : Binding is rapid, saturable and requires phosphorylation of the PDGFR at Y751, but does not require PDGF dependent phosphorylation of PI3K
Klinghoffer et al., Mol Cell Biol 1996 : Thus, activation of PI3K requires not only binding of PI3K to the tyrosine phosphorylated PDGFR but accumulation of GTP bound Ras as well
Quon et al., Biochem Biophys Res Commun 1996 : In adipose cells, stimulation of endogenous PDGF receptors (PDGF-R) results in increased PI3K activity without causing recruitment of GLUT4