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NFKB1 — PHF15
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Contzler et al., Biochem Biophys Res Commun 2006
:
Histone acetyltransferase
HBO1 inhibits
NF-kappaB activity by coactivator sequestration ... Since the androgen receptor and NF-kappaB transcription factors crossmodulate their transcriptional activity, we investigated whether
HBO1 regulates
NF-kappaB signaling ... Here, we report that in 293T cells
HBO1 reduced dose-dependently
NF-kappaB activity stimulated by TNFalpha, or by overexpressing p65/RelA, RelB, or cRel ... Electrophoretic mobility-shift assays demonstrated that HBO1 was neither perturbing the formation of p65/RelA DNA complexes nor binding itself to the kappaB consensus sequence or to p65/RelA, suggesting that
HBO1 reduced
NF-kappaB activity by squelching a cofactor
Coles et al., Proc Natl Acad Sci U S A 2010
(Inflammation) :
We have generated Ing4-deficient mice to explore the
role of
Ing4 in development, tumorigenesis, and in
NF-kappaB signaling