Ghosh et al., Oncogene 2005
(Glioblastoma) :
Surprisingly, inhibition of PI3 kinase (PI3K) activity, which in turn inhibited AKT activation, significantly increased the DNA binding activity of Stat3 in U87 and D54 cells
Lin et al., Virology 2010
(Inflammation...) :
ARV S1133 activated PI 3-kinase dependent Akt/NF-kappaB and p70 S6 kinase, as well as Stat3 ; however, p70 S6 kinase was not involved in ARV S1133 mediated effects
Wang et al., PloS one 2010
(Reperfusion Injury) :
TLR4-deficiency was also associated with decreased phosphorylation of PI-3K and AKT, but increased activation of STAT3