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PDLIM7 — PIK3R1
Text-mined interactions from Literome
Mainou et al., J Virol 2007
(Cell Transformation, Viral...) :
CTAR1 is necessary for
LMP1 mediated transformation as well as activation of
PI3K signaling and induction of cell cycle markers associated with G ( 1 ) /S transition
Lambert et al., J Immunol 2007
:
We also demonstrate that the
LMP1 dependent p38 and
PI3K activation regulates IL-10 induction through discrete mechanisms
Shair et al., Cancer Res 2008
:
However, constitutive activation of Akt alone did not alter cell growth, suggesting that both
PI3K/Akt and NF-kappaB activation are
required by
LMP1
Hatton et al., PloS one 2012
(Lymphoma, B-Cell) :
Using small molecule inhibition and siRNA strategies in human B cell lines expressing a chimeric, signaling-inducible LMP1 protein, nerve growth factor receptor (NGFR)-LMP1, we show that
NGFR-LMP1 utilizes Syk to
activate PI3K/Akt signaling and induce IL-10 production ... Whereas Src kinases are often required for Syk activation, we show here that
PI3K/Akt activation and autocrine IL-10 production by
NGFR-LMP1 involves the Src family kinase Fyn