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MDM2 — PIM1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
MDM2
—
PIM1
(direct interaction, enzymatic study)
Wood et al., FEBS Lett 2009*
-
IRef Biogrid Interaction:
MDM2
—
PIM1
(direct interaction, pull down)
Hogan et al., J Biol Chem 2008*
-
IRef Biogrid Interaction:
MDM2
—
PIM1
(direct interaction, enzymatic study)
Hogan et al., J Biol Chem 2008*
-
IRef Biogrid Interaction:
MDM2
—
PIM1
(physical association, affinity chromatography technology)
Hogan et al., J Biol Chem 2008*
-
IRef Intact Interaction:
MDM2
—
PIM1
(phosphorylation reaction, protein kinase assay)
Wood et al., FEBS Lett 2009*
Text-mined interactions from Literome
Ionov et al., Anticancer Res 2003
(Burkitt Lymphoma) :
Because Pim-1 is known to regulate apoptosis and human Mdm2 (HDM2) contains a consensus Pim-1 phosphorylation site, the possible
role of
Pim-1 in modulating
HDM2 was examined ... The nuclear location of
Pim-1 is
essential for its regulation of the levels of
HDM2 protein, and possibly for additional biological activities of this protein kinase
Hogan et al., J Biol Chem 2008
(Lymphoma, Mantle-Cell) :
Surprisingly, at high levels of Pim expression, as would occur in tumors, active, but not inactive,
Pim-1 or Pim-2
blocks the degradation of both p53 and
Mdm2 in a manner that is independent of Mdm2 phosphorylation, leading to increased p53 levels and, proportionately, p53 dependent transactivation ... Additionally,
Pim-1 induces endogenous ARF, p53,
Mdm2 , and p21 in primary murine embryo fibroblasts and stimulates senescence associated beta-galactosidase levels, consistent with the induction of senescence