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BDNF — PLAT

Text-mined interactions from Literome

Fiumelli et al., Eur J Neurosci 1999 : Induction of tPA expression by BDNF is accompanied by an increase in the proteolytic activity of tPA associated with cortical neurons and a release of tPA into the extracellular space ... Release of tPA induced by BDNF depends on extracellular Ca2+ since it is markedly reduced in the presence of ethylene glycol-bis ( beta-aminoethylether ) -N, N,N ', N'-tetraacetic acid ( EGTA ) ... Up-regulation of tPA expression by BDNF is followed by the induction of plasminogen activator inhibitor 2 ( PAI-2 ), an inhibitor of tPA ... Together these results suggest that activation of tPA by BDNF may contribute to structural changes associated with neuronal development or synaptic plasticity
Taishi et al., Am J Physiol Regul Integr Comp Physiol 2001 (Sleep Deprivation) : mRNA expression of four molecules [brain derived neurotrophic factor ( BDNF ), activity regulated cytoskeleton associated protein ( Arc ), matrix metalloproteinase-9 (MMP-9), and tissue plasminogen activator (tPA) ] was determined after 8 h of sleep deprivation and after 6 h of a mild increase in ambient temperature, a condition that enhances sleep in rats
Lochner et al., Dev Neurobiol 2008 (Synaptic Transmission) : These results support the hypothesis that tPA mediates synaptic activation of BDNF by demonstrating that tPA, plasminogen, and proBDNF colocalize in DCGs in spines, where these neuromodulators can undergo activity dependent release and then interact and/or mediate changes that influence synaptic efficacy