Gene interactions and pathways from curated databases and text-mining

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CSF1 — PLAU

Text-mined interactions from Literome

Costelloe et al., J Leukoc Biol 1999 : PAI-2 mRNA levels generally varied inversely from those of its target, urokinase-type plasminogen activator ( uPA ), and the macrophage growth factor CSF-1 , which induces uPA , inhibited PAI-2 expression in cells treated subsequently with LPS
Fowles et al., Biochem J 2000 : Mutation of the expressed CSF-1R at either Y807 or Y559, sites of receptor tyrosine phosphorylation implicated in signal transduction, reduced but did not abolish uPA promoter activation by CSF-1
Irvine et al., FASEB J 2006 (Inflammation) : CYC10268 also inhibited CSF-1 regulated signaling ( Akt, ERK-1/2 ), gene expression ( urokinase plasminogen activator , toll-like receptor 9, and apolipoprotein E ), and priming of LPS-inducible cytokine production in BMM