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CSF1 — PLAU
Text-mined interactions from Literome
Costelloe et al., J Leukoc Biol 1999
:
PAI-2 mRNA levels generally varied inversely from those of its target, urokinase-type plasminogen activator ( uPA ), and the macrophage growth factor
CSF-1 , which
induces uPA , inhibited PAI-2 expression in cells treated subsequently with LPS
Fowles et al., Biochem J 2000
:
Mutation of the expressed CSF-1R at either Y807 or Y559, sites of receptor tyrosine phosphorylation implicated in signal transduction, reduced but did not abolish
uPA promoter
activation by
CSF-1
Irvine et al., FASEB J 2006
(Inflammation) :
CYC10268 also
inhibited CSF-1 regulated signaling ( Akt, ERK-1/2 ), gene expression (
urokinase plasminogen activator , toll-like receptor 9, and apolipoprotein E ), and priming of LPS-inducible cytokine production in BMM