◀ Back to SYK

PLCG1 — SYK

Pathways - manually collected, often from reviews:

• KEGG Fc epsilon RI signaling pathway: SYK → PLCG1/PLCG2 (protein-protein, activation)
• KEGG Fc gamma R-mediated phagocytosis: SYK → PLCG1/PLCG2 (protein-protein, activation)
• NCI Pathway Database Class I PI3K signaling events: None → Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) (modification, collaborate)
  Rodriguez et al., Biochem J 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) (modification, activates) Rodriguez et al., Biochem J 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) → None (modification, activates) Rodriguez et al., Biochem J 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database Class I PI3K signaling events: PLC-gamma family (PLCG1/PLCG2) → Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) (modification, collaborate)
  Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Class I PI3K signaling events: PLC-gamma family (PLCG1/PLCG2) → Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) (modification, collaborate)
  Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) → Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) (modification, collaborate)
  Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
  Evidence: mutant phenotype, physical interaction, other species
• Reactome Reaction: SYK → PLCG1 (reaction) Gross et al., J Biol Chem 1999, Carpenter et al., Exp Cell Res 1999, Nore et al., Biochim Biophys Acta 2003, Sekiya et al., J Biol Chem 2004, Humphries et al., J Biol Chem 2004, Reeve et al., J Immunol 2009, Ormsby et al., Blood 2011, Dusi et al., Biochem Biophys Res Commun 1994, Kawakami et al., Mol Cell Biol 1994, Rawlings et al., Science 1996, Park et al., Immunity 1996, Law et al., Mol Cell Biol 1996, Bubeck Wardenburg et al., J Biol Chem 1996, Deckert et al., Immunity 1996, Hendricks-Taylor et al., J Biol Chem 1997
• Reactome Reaction: SYK → PLCG1 (indirect_complex) Brooks et al., J Immunol 2000, Marshall et al., J Exp Med 2000, Fujimoto et al., Immunity 2000, Baba et al., Proc Natl Acad Sci U S A 2001, Rodriguez et al., J Biol Chem 2001, Chiu et al., EMBO J 2002, Xu et al., J Immunol 2002, Coggeshall et al., Proc Natl Acad Sci U S A 1992, Sekiya et al., J Biol Chem 2004, Brooks et al., J Immunol 2004, Roifman et al., Biochem Biophys Res Commun 1992, Kim et al., Mol Cell Biol 2004, Carter et al., Proc Natl Acad Sci U S A 1991, Dusi et al., Biochem Biophys Res Commun 1994, Weng et al., J Biol Chem 1994, Roifman et al., Biochem Biophys Res Commun 1993, Chalupny et al., EMBO J 1993, Uckun et al., J Biol Chem 1993, de Weers et al., J Biol Chem 1994, Saxton et al., J Immunol 1994, Smit et al., J Biol Chem 1996, Law et al., Mol Cell Biol 1996, Kuwahara et al., Int Immunol 1996, Harmer et al., Mol Cell Biol 1997, Fu et al., J Biol Chem 1997, Bae et al., J Biol Chem 1998, Fu et al., Immunity 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SYK — PLCG1 (physical association, affinity chromatography technology) Sidorenko et al., Proc Natl Acad Sci U S A 1995*
• IRef Dip Interaction: SYK — PLCG1 (physical association, coimmunoprecipitation) Sidorenko et al., Proc Natl Acad Sci U S A 1995*
• IRef Hprd Interaction: SYK — PLCG1 (in vitro) Brill et al., Anal Chem 2004, Kim et al., J Biol Chem 1990*, Liao et al., Biochem Biophys Res Commun 1993*, Law et al., Mol Cell Biol 1996, Sidorenko et al., Immunity 1996*
• IRef Hprd Interaction: SYK — PLCG1 (in vivo) Brill et al., Anal Chem 2004, Kim et al., J Biol Chem 1990*, Liao et al., Biochem Biophys Res Commun 1993*, Law et al., Mol Cell Biol 1996, Sidorenko et al., Immunity 1996*
• IRef Intact Interaction: Complex of SYK-PLCG1-CD22-PTPN6 (association, coimmunoprecipitation) Law et al., J Exp Med 1996*
• IRef Intact Interaction: Complex of SH3BP2-PLCG1-SYK-VAV1 (association, pull down) Foucault et al., Blood 2005
• IRef Intact Interaction: SYK — PLCG1 (association, coimmunoprecipitation) Law et al., Mol Cell Biol 1996
• IRef Intact Interaction: SYK — PLCG1 (association, pull down) Law et al., Mol Cell Biol 1996
• IRef Ophid Interaction: SYK — PLCG1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: SYK — PLCG1 (aggregation, confirmational text mining) Sidorenko et al., Immunity 1996*

Text-mined interactions from Literome

Martelli et al., Blood 2000 : Using Jurkat cell lines deficient in ZAP70/Syk ( P116 ) or LAT ( ANJ3 ) expression, CD2 dependent PLCgamma-1 and SLP-76 tyrosine phosphorylation required expression both of ZAP70 or Syk and of LAT
Yamamoto et al., FEBS Lett 2001 : We also show that Tec family PTKs enhanced endogenous phospholipase C (PLC)-gamma1 phosphorylation induced by CD8/zeta and Syk in 293T cells
Inubushi et al., J Gen Virol 2008 : Moreover, Syk mediated phosphorylation of phospholipase C-gamma1 was downregulated by NS5A
Ryu et al., Cell Calcium 2009 (Calcium Signaling) : In contrast, antigen induced tyrosine phosphorylation of phospholipase Cgamma was not affected by clathrin-knockdown and tyrosine phosphorylation of Syk and degranulation were partially inhibited in clathrin-knockdown cells
Xia et al., Int Immunopharmacol 2013 : Furthermore, we found that MED suppressed antigen induced activation of Syk , and subsequently inhibited the phosphorylation of PLC?1 , Akt, and MAPKs such as extracellular signal regulated kinase ( ERK ), c-jun N-terminal kinase ( JNK ), and p38 in mast cells
Qin et al., Biochem J 1995 : Taken together, these data suggested that one possible role of p72syk was to activate PLC gamma 1 , at least in part through tyrosine phosphorylation, and then to trigger calcium mobilization in pig peripheral blood lymphocytes in response to hydrogen peroxide stimulation
Law et al., Mol Cell Biol 1996 : Thus, an optimal kinase activity of Syk and an interaction between the linker region of Syk with PLC-gamma1 are required for the tyrosyl phosphorylation of PLC-gamma1