◀ Back to CBL
CBL — PLCG2
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
CBL
→
PLCG2
(indirect_complex)
Brooks et al., J Immunol 2000, Marshall et al., J Exp Med 2000, Fujimoto et al., Immunity 2000, Baba et al., Proc Natl Acad Sci U S A 2001, Rodriguez et al., J Biol Chem 2001, Chiu et al., EMBO J 2002, Xu et al., J Immunol 2002, Coggeshall et al., Proc Natl Acad Sci U S A 1992, Sekiya et al., J Biol Chem 2004, Brooks et al., J Immunol 2004, Roifman et al., Biochem Biophys Res Commun 1992, Kim et al., Mol Cell Biol 2004, Carter et al., Proc Natl Acad Sci U S A 1991, Weng et al., J Biol Chem 1994, Roifman et al., Biochem Biophys Res Commun 1993, Chalupny et al., EMBO J 1993, Uckun et al., J Biol Chem 1993, de Weers et al., J Biol Chem 1994, Saxton et al., J Immunol 1994, Smit et al., J Biol Chem 1996, Kuwahara et al., Int Immunol 1996, Harmer et al., Mol Cell Biol 1997, Fu et al., J Biol Chem 1997, Bae et al., J Biol Chem 1998, Fu et al., Immunity 1998
Text-mined interactions from Literome
Yasuda et al., J Exp Med 2000
:
A possible explanation for the
involvement of
Cbl in
PLC-gamma2 activation was provided by findings that Cbl interacts via its Src homology 2 (SH2) domain with B cell linker protein (BLNK) after BCR ligation ... As a
consequence of the interaction between
Cbl and BLNK, the BCR induced recruitment of PLC-gamma2 to BLNK and the subsequent
PLC-gamma2 tyrosine phosphorylation were inhibited ... Thus, our data suggest that
Cbl negatively
regulates the PLC-gamma2 pathway by inhibiting the association of
PLC-gamma2 with BLNK
Yasuda et al., J Exp Med 2002
(Calcium Signaling) :
Cbl-b positively
regulates Btk mediated activation of
phospholipase C-gamma2 in B cells ... These results demonstrate that
Cbl-b positively
regulates BCR mediated Ca2+ signaling, most likely by influencing the
Btk/BLNK/PLC-gamma2 complex formation
Zhang et al., J Immunol 2004
(Calcium Signaling...) :
Fc epsilon RI-induced tyrosine phosphorylation of total cellular proteins, Syk, and
phospholipase C-gamma was also
enhanced by
Cbl-b deficiency, whereas receptor initiated phosphorylation of Vav, JNK, and p38 kinases was not changed in these cells
Peruzzi et al., J Immunol 2007
(Calcium Signaling) :
We found that
CIN85 overexpression
inhibits the FcepsilonRI induced tyrosine phosphorylation of
phospholipase Cgamma , thus altering calcium mobilization