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CSF1 — PLCG2
Text-mined interactions from Literome
Dearden-Badet et al., Cell Signal 2005
:
M-CSF stimulation
induced rapid
PLC-gamma2 translocation and phosphorylation from the cytosolic compartment to the cell periphery
Jack et al., Blood 2009
(MAP Kinase Signaling System) :
G-CSF specifically activated signal transducer and activator of transcription 3 and induced Src homology region 2 domain containing phosphatase 2 ( SHP2 ) phosphorylation, whereas
M-CSF preferentially
activated phospholipase Cgamma2 , and thereby extracellular signal regulated kinase ( ERK ), to stabilize c-Fos and stimulate CCAAT/enhancer binding protein ( C/EBP)alpha(S21 ) phosphorylation
Bourette et al., EMBO J 1997
:
Sequential
activation of phoshatidylinositol 3-kinase and
phospholipase C-gamma2 by the
M-CSF receptor is necessary for differentiation signaling ... At variance with previous reports,
M-CSF induced rapid and transient tyrosine phosphorylation of
PLC-gamma2 in myeloid FDC-P1 cells and this activation required the activity of the PI3-kinase pathway ... Since the Fms Y807F mutation abrogates the differentiation signal when expressed in FDC-P1 cells and since this phenotype could be reproduced by a specific inhibitor of PLC-gamma, we propose that a balance between the activities of
PLC-gamma2 and PI3-kinase in
response to
M-CSF is required for cell differentiation