Gene interactions and pathways from curated databases and text-mining

◀ Back to CSF1

CSF1 — PLCG2

Text-mined interactions from Literome

Dearden-Badet et al., Cell Signal 2005 : M-CSF stimulation induced rapid PLC-gamma2 translocation and phosphorylation from the cytosolic compartment to the cell periphery
Jack et al., Blood 2009 (MAP Kinase Signaling System) : G-CSF specifically activated signal transducer and activator of transcription 3 and induced Src homology region 2 domain containing phosphatase 2 ( SHP2 ) phosphorylation, whereas M-CSF preferentially activated phospholipase Cgamma2 , and thereby extracellular signal regulated kinase ( ERK ), to stabilize c-Fos and stimulate CCAAT/enhancer binding protein ( C/EBP)alpha(S21 ) phosphorylation
Bourette et al., EMBO J 1997 : Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signaling ... At variance with previous reports, M-CSF induced rapid and transient tyrosine phosphorylation of PLC-gamma2 in myeloid FDC-P1 cells and this activation required the activity of the PI3-kinase pathway ... Since the Fms Y807F mutation abrogates the differentiation signal when expressed in FDC-P1 cells and since this phenotype could be reproduced by a specific inhibitor of PLC-gamma, we propose that a balance between the activities of PLC-gamma2 and PI3-kinase in response to M-CSF is required for cell differentiation