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KRT8 — PLG
Text-mined interactions from Literome
Hembrough et al., Biochem J 1996
(Breast Neoplasms) :
Cytokeratin 8 released by breast carcinoma cells in vitro binds plasminogen and tissue-type plasminogen activator and
promotes plasminogen activation ... The released
CK 8 is in the form of variably sized polymers that bind plasminogen and
promote the activation of [ Glu1 ]
plasminogen and [ Lys78 ] plasminogen by single-chain tissue-type plasminogen activator ( sct-PA ) ... To assess the mechanism by which
CK 8 promotes
plasminogen activation, CK 8 was purified from rat hepatocytes and immobilized in microtitre plates
Kralovich et al., J Protein Chem 1998
:
Nevertheless,
CK8f still
promoted plasminogen activation, probably reflecting the fact that CK8f was purified in dimeric or tetrameric form ... These studies demonstrate that
CK8 may
promote plasminogen activation by t-PA only when present in an oligomerized state