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PLG — RELA
Text-mined interactions from Literome
Wang et al., Oncogene 1999
(Adenocarcinoma...) :
Overexpression of urokinase-type
plasminogen activator in pancreatic adenocarcinoma is
regulated by constitutively activated
RelA ... We report that the urokinase-type
plasminogen activator ( uPA ), one of the critical proteases involved in tumor invasion and metastasis, is overexpressed in pancreatic tumor cells and its overexpression is
induced by constitutive
RelA activity
Yoshizaki et al., Histol Histopathol 2002
(Carcinoma...) :
LMP-1 down-regulates expression of E-cadherin,
induces matrix metalloproteinase-9 and urokinase
type-plasminogen activator through activation of
NF-kappaB and AP-1, and enhances cell motility via ets-1 activation
Syrovets et al., Thromb Haemost 2002
(Inflammation) :
Ciglitazone activates PPAR gamma as shown by a novel surface plasmon resonance analysis and inhibits the
plasmin induced
activation of
NF-kappa B and AP-1
Mahabeleshwar et al., J Biol Chem 2003
(Anoxia...) :
Luciferase reporter gene assay indicated that Lck induces
NFkappaB dependent urokinase type
plasminogen activator ( uPA ) promoter activity in presence of H/R
Min et al., Biochem Biophys Res Commun 2003
:
Furthermore,
plasminogen stimulated CREB and
NF-kappaB DNA binding activity, and this activation was also reduced by trolox and NAC
Iwasaki et al., Atherosclerosis 2008
(Hyperglycemia) :
High glucose
induces plasminogen activator inhibitor-1 expression through Rho/Rho-kinase mediated
NF-kappaB activation in bovine aortic endothelial cells
Zare et al., J Leukoc Biol 2008
:
In contrast,
Plg production did not
require NF-kappaB , was only partly down-regulated by p38 MAPK inhibitor, and was efficiently inhibited by insulin, indicating a different mechanism for its induction
Ng et al., J Biol Chem 1994
:
Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8, TNF stimulated gene 6, and
plasminogen activation inhibitor-2 genes and the
activation of
NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested