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MMP2 — POLDIP2
Text-mined interactions from Literome
Ruhul Amin et al., Cancer Res 2003
(MAP Kinase Signaling System) :
Finally, reintroduction of wild-type SHP-2 into SHP-2 mutant cells rescued Erk and
p38 activation , and also
MMP-2 secretion, whereas dominant negative SHP-2 could block the Con A-dependent activation of Erk and p38
Ke et al., Int J Cancer 2006
:
Transient or stable transfection of ErbB2 cDNA to HB2 cells upregulated the transcripts and the activity of the MMP-2/-9 gene promoter ; the upregulation of
MMP-2/-9 expression was
mediated by
p38 mitogen activated protein kinase ( p38 MAPK ) and phosphatidylinositol 3-kinase (PI3K)
Milkiewicz et al., J Cell Physiol 2006
:
Nitric oxide and
p38 MAP kinase mediate shear stress dependent
inhibition of
MMP-2 production in microvascular endothelial cells
Xu et al., Mol Pharmacol 2006
(Neoplasm Invasiveness...) :
We have shown that genistein blocks prostate cancer ( PCa ) cell invasion, that
p38 mitogen activated protein ( MAP ) kinase
regulates activation of
matrix metalloproteinase type 2 (MMP-2) and cell invasion, and that genistein prevents transforming growth factor beta ( TGFbeta ) from activating p38 MAP kinase
Park et al., Cancer Res 2006
(Glioblastoma...) :
In addition, inhibitors of epidermal growth factor receptor ( EGFR ; AG490 and AG1478 ), Src ( PP2 ), and
p38 ( SB203580 ), EGFR neutralizing antibody, and transfection of DN-Src and DN-p38 significantly
blocked IR-induced Akt phosphorylation and
MMP-2 secretion
Pan et al., Mol Biol Rep 2013
(MAP Kinase Signaling System...) :
SDF-1a upregulation of
MMP-2 is
mediated by
p38 MAPK signaling in pancreatic cancer cell lines