Gene interactions and pathways from curated databases and text-mining

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MMP2 — POLDIP2

Text-mined interactions from Literome

Ruhul Amin et al., Cancer Res 2003 (MAP Kinase Signaling System) : Finally, reintroduction of wild-type SHP-2 into SHP-2 mutant cells rescued Erk and p38 activation , and also MMP-2 secretion, whereas dominant negative SHP-2 could block the Con A-dependent activation of Erk and p38
Ke et al., Int J Cancer 2006 : Transient or stable transfection of ErbB2 cDNA to HB2 cells upregulated the transcripts and the activity of the MMP-2/-9 gene promoter ; the upregulation of MMP-2/-9 expression was mediated by p38 mitogen activated protein kinase ( p38 MAPK ) and phosphatidylinositol 3-kinase (PI3K)
Milkiewicz et al., J Cell Physiol 2006 : Nitric oxide and p38 MAP kinase mediate shear stress dependent inhibition of MMP-2 production in microvascular endothelial cells
Xu et al., Mol Pharmacol 2006 (Neoplasm Invasiveness...) : We have shown that genistein blocks prostate cancer ( PCa ) cell invasion, that p38 mitogen activated protein ( MAP ) kinase regulates activation of matrix metalloproteinase type 2 (MMP-2) and cell invasion, and that genistein prevents transforming growth factor beta ( TGFbeta ) from activating p38 MAP kinase
Park et al., Cancer Res 2006 (Glioblastoma...) : In addition, inhibitors of epidermal growth factor receptor ( EGFR ; AG490 and AG1478 ), Src ( PP2 ), and p38 ( SB203580 ), EGFR neutralizing antibody, and transfection of DN-Src and DN-p38 significantly blocked IR-induced Akt phosphorylation and MMP-2 secretion
Pan et al., Mol Biol Rep 2013 (MAP Kinase Signaling System...) : SDF-1a upregulation of MMP-2 is mediated by p38 MAPK signaling in pancreatic cancer cell lines