Tsiani et al., Am J Physiol Endocrinol Metab 2002
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We postulated that mesangial cells exposed to high glucose and to endothelin-1 (ET-1), angiotensin II (ANG II), and platelet derived growth factor ( PDGF ) demonstrate enhanced p38 activity and subsequent activation of the cAMP responsive element binding ( CREB ) transcription factor Kenzel et al., Infect Immun 2009
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GBS induced, MyD88 dependent phosphorylation of the mitogen activated protein kinase p38 activated the transcription factor AP-1 and early growth response factor 1 (Egr-1) but not NF-kappaB
Che et al., Biochim Biophys Acta 2013
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Further studies identified that p27 inhibition of COX-2 expression was specifically due to phosphorylation of transcription factor cAMP response element binding ( CREB ) phosphorylation mediated by p38ß and p38d