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HLA-DRA — POU2F2
Text-mined interactions from Literome
Abdulkadir et al., J Exp Med 1995
:
Here we show that the lymphoid-specific transcription factor
Oct-2A plays a critical role in
HLA-DRA gene expression in class II-positive B cell lines, and that the high mobility group protein (HMG) I/Y binds to multiple sites within the DRA promoter, including the Oct-2A binding site ... Coexpression of HMG I/Y and
Oct-2 in cell lines lacking Oct-2
results in high levels of
HLA-DRA gene expression, and in vitro DNA binding studies reveal that HMG I/Y stimulates Oct-2A binding to the HLA-DRA promoter ... By contrast,
Oct-2A is not
involved in the IFN-gamma induction of the
HLA-DRA gene in HeLa cells, but antisense HMG I/Y dramatically decreases the level of induction
Abdulkadir et al., J Leukoc Biol 1998
:
We have previously determined that HMG I(Y) and
Oct-2A cooperatively
activate HLA-DRA gene expression, most likely due to the ability of HMG I(Y) to selectively recruit Oct-2A to the octamer motif ... These studies support the view that HMG I(Y) is an important cofactor for
HLA-DRA gene
activation by
Oct-2A and provide insights into its mechanism of action