Gene interactions and pathways from curated databases and text-mining

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FOXO1 — PPARGC1A

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

  • STRING interaction: PPARGC1A — FOXO1 (interaction, mapped from bind kegg_pathways)
  • STRING interaction: FOXO1 — PPARGC1A (interaction, mapped from bind kegg_pathways)

Text-mined interactions from Literome

Southgate et al., FASEB J 2005 (Insulin Resistance) : PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin stimulated skeletal muscle
Chang et al., Endocrinology 2006 : The expression of PGC-1alpha in muscle is regulated by myocyte enhancer factor 2 and Forkhead in rhabdomyosarcoma , two transcription factors implicated in terminal muscle differentiation
Schilling et al., Nature 2006 : Puigserver et al. show that the transcription factor FOXO1 and the transcriptional co-activator PGC-1alpha act synergistically to stimulate the expression of genes in the gluconeogenesis pathway and propose that PGC-1alpha acts , in part, directly through FOXO1
Hu et al., Circ Res 2008 (Disease Models, Animal...) : Both SUR1-tg and Kir6.2 KO mice had decreased FOXO1 after transverse aortic constriction, in agreement with the reports that a decrease of FOXO1 can repress PGC-1alpha expression