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PPP1R12A — RHOA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
RHOA
—
PPP1R12A
(colocalization, biochemical)
Havugimana et al., Cell 2012
-
MIPS CORUM MRIP-MBS-RHOA complex:
MRIP-MBS-RHOA complex complex (MPRIP-PPP1R12A-RHOA)
Surks et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
PPP1R12A
—
RHOA
(in vivo)
Nakai et al., Blood 1997*
-
IRef Hprd Interaction:
PPP1R12A
—
RHOA
(in vitro)
Nakai et al., Blood 1997*
-
IRef Intact Interaction:
Complex of 13 proteins
(association, anti bait coimmunoprecipitation)
Koga et al., J Biol Chem 2005*
-
IRef Ophid Interaction:
PPP1R12A
—
RHOA
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
PPP1R12A
—
RHOA
(aggregation, confirmational text mining)
Nakai et al., Blood 1997*
-
STRING interaction:
RHOA
—
PPP1R12A
(interaction, mapped from kegg_pathways)
-
STRING interaction:
RHOA
—
PPP1R12A
(interaction, mapped from reactome)
-
STRING interaction:
PPP1R12A
—
RHOA
(interaction, mapped from kegg_pathways)
-
STRING interaction:
PPP1R12A
—
RHOA
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
Surks et al., J Biol Chem 2003
:
M-RIP can assemble a complex containing both RhoA and MBS, suggesting that M-RIP may play a role in
myosin phosphatase regulation by
RhoA
Lartey et al., Biol Reprod 2006
:
We tested the hypothesis that the uterine quiescence observed during gestation is mediated by an increase in RND protein expression inhibiting
RHOA-ROCK mediated
PPP1R12A phosphorylation
Riddick et al., J Cell Biochem 2008
:
Because myosin phosphatase-rho interacting protein binds both RhoA and MLCP, we investigated whether myosin phosphatase-rho interacting protein was required for
RhoA/ROCK mediated
myosin phosphatase regulation
da Silva-Santos et al., Crit Care Med 2009
(Disease Models, Animal...) :
Our findings revealed an impaired
Rho-A/Rho-kinase mediated phosphorylation of
MYPT1 in vessels from endotoxemic animals in a cyclic guanosine monophosphate dependent manner, suggesting that changes in mechanisms involved in calcium sensitization play a pivotal role in cardiovascular changes observed in septic shock
Ramachandran et al., Invest Ophthalmol Vis Sci 2011
:
Consequent inhibition of
RhoA activity
reduces the phosphorylation of
MYPT1 at Thr853, leading to a reduction in MLC phosphorylation and actomyosin contraction
Xu et al., Lab Invest 2012
(Liver Cirrhosis, Experimental) :
Sal B decreased ET-1 induced
RhoA and Rho associated coiled coil forming protein kinase ( ROCK) II activation by 66.84 % and by 76.79 %, respectively, and
inhibited Thr ( 696 ) phosphorylation of
MYPT1 by 80.09 %