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GNRH1 — PRKAA1

Text-mined interactions from Literome

Roland et al., Endocrinology 2011 (Prenatal Exposure Delayed Effects) : To assess whether AMPK activation contributed to the metformin induced reduction in GnRH neuron activity, the AMPK antagonist compound C was acutely applied to cells
Andrade et al., Mol Endocrinol 2013 : Using LßT2 cells, we show that GnRH rapidly ( 5 minutes ) triggers activating phosphorylation of AMP activated protein kinase (AMPK) up to 5-fold ; this stimulation is enhanced by insulin through increased total AMPKa levels and activity ... Finally, in primary mouse pituitary cells, GnRH also stimulates AMPK, and AMPK inhibition suppresses GnRH stimulated LHß transcription ... These studies indicate a novel role for AMPK in GnRH stimulated transcription in pituitary gonadotropes and a potential common mechanism for GnRH and metabolic modulation of fertility