Mancini et al., Oncogene 2004
:
We conclude M-CSF mediated activation of PKCalpha can potentiate FMIP action to initiate survival/differentiation signaling
Whetton et al., J Cell Biol 1994
(Second Messenger Systems) :
Furthermore, M-CSF , but not SCF, can increase the levels of PKC alpha ( PKC alpha ) expression and stimulate the translocation of PKC alpha to the nucleus
Pierce et al., J Cell Biol 1998
:
Thus, M-CSF stimulated translocation of PKCalpha to the nucleus is a signal associated with macrophage development in primary mammalian hematopoietic progenitor cells, and this signal can be mimicked by ectopic PKAC, which is also expressed in the nucleus