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EGFR — PRKCA
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wang et al., Cancer Res 2007
(Carcinoma, Squamous Cell) :
GM3- and CD82 induced inhibition of
EGFR signaling
requires PKC-alpha translocation and serine/threonine phosphorylation, which eventually triggers EGFR Thr654 phosphorylation and receptor internalization ... Disruption of the membrane with methyl-beta-cyclodextrin dissociates the EGFR/GM3/caveolin-1/CD82/PKC-alpha complex and prevents the inhibitory
effect of
PKC-alpha on
EGFR phosphorylation, suggesting that caveolin-1, CD82, and ganglioside interact with EGFR and PKC-alpha within intact cholesterol enriched membrane microdomains
Wang et al., Toxicol Appl Pharmacol 2009
:
Inhibition of SFK or
PKCalpha activities did not
affect EGFR phosphorylation, while knockdown of EGFR blocked SFK phosphorylation and PKCalpha activation following Pb. Together, these results indicate that immediate activation of EGFR in response to Pb is obligatory for activation of SFK and PKCalpha and subsequent the Ras-Raf-1-MKK1/2-ERK1/2 signaling cascade
Lee et al., J Cell Physiol 2010
(MAP Kinase Signaling System) :
Taken together, these data suggest that in A549 cells, TNF-alpha induces MMP-9 expression via the
TNFR1/TRAF2/PKCalpha dependent JNK1/2/c-Jun and
c-Src/EGFR/PI3K/Akt pathways
Fitzer-Attas et al., FEBS Lett 1994
:
In these cells over-expression of
PKC-alpha reduced the expression of
epidermal growth factor (EGF) receptor molecules [ ( 1990 ) J. Biol. Chem. 265, 13290-13296 ]