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GH1 — PRLR

Pathways - manually collected, often from reviews:

• Reactome Reaction: PRLR → GH1 (reaction) Walsh et al., J Mol Biol 2006*
• Reactome Reaction: PRLR → GH1 (indirect_complex) Li et al., Mol Cell Biol 2004, Walsh et al., J Mol Biol 2006*, Broutin et al., J Biol Chem 2010*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: GH1 — PRLR Somers et al., Nature 1994*
• IRef Bind_translation Interaction: GH1 — PRLR (x-ray crystallography) Somers et al., Nature 1994*
• IRef Dip Interaction: GH1 — PRLR (direct interaction, x-ray crystallography) Somers et al., Nature 1994*
• IRef Hprd Interaction: PRLR — GH1 (in vitro) Kopchick et al., Transgenic Res 1998*
• IRef Intact Interaction: GH1 — PRLR (direct interaction, x-ray crystallography) Somers et al., Nature 1994*
• IRef Ophid Interaction: GH1 — PRLR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Galsgaard et al., J Biol Chem 1999 : Expression of the prolactin receptor (PRLR) gene is increased in pancreatic islets during pregnancy and in vitro in insulin producing cells by growth hormone (GH) and prolactin (PRL)
Xu et al., Mol Endocrinol 2011 (Breast Neoplasms) : Growth hormone signaling in human T47D breast cancer cells : potential role for a growth hormone receptor-prolactin receptor complex
Andersen et al., J Biol Chem 1979 : Modification of human growth hormone and human placental lactogen with ethoxyformic anhydride resulted in a loss of the ability of these lactogenic hormones to bind to the prolactin receptor
Wiedermann et al., Naunyn Schmiedebergs Arch Pharmacol 1993 : As the effect of growth hormone on neutrophils is mediated by the prolactin receptor , its inhibition by octreotide was also tested using prolactin as priming agent