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NOTCH1 — PROX1

Text-mined interactions from Literome

Kang et al., Blood 2010 : We found that Notch signal down-regulates Prox1 and COUP-TFII through Hey1 and Hey2 and that activated Notch receptor suppresses the lymphatic phenotypes and induces the arterial cell fate
Kaltezioti et al., PLoS Biol 2010 : Physiological levels of Prox1 in this tissue are sufficient to allow binding at Notch1 promoter and they are critical for proper Notch1 transcriptional regulation in vivo ... Gain-of-function studies in the chick neural tube and mouse NPCs suggest that Prox1 mediated suppression of Notch1 relieves its inhibition on neurogenesis and allows NPCs to exit the cell cycle and differentiate ... Moreover, loss-of-function in the chick neural tube shows that Prox1 is necessary for suppression of Notch1 outside the ventricular zone, inhibition of active Notch signaling, down-regulation of NPC markers, and completion of neuronal differentiation program ... Together these data suggest that Prox1 inhibits Notch1 gene expression to control the balance between NPC self-renewal and neuronal differentiation
Yoo et al., PLoS Pathog 2012 (Herpesviridae Infections) : Opposing regulation of PROX1 by interleukin-3 receptor and NOTCH directs differential host cell fate reprogramming by Kaposi sarcoma herpes virus ... Here, we report that IL3 receptor alpha ( IL3Ra ) and NOTCH play integral roles in the host cell type-specific regulation of PROX1 by KSHV
Murtomaki et al., Development 2013 : Expression of a constitutively active Notch1 protein in Prox1+ cells suppressed endothelial Prox1 from E9.75 to E13.5, resulting in misspecified lymphatic endothelial cells based upon reduced expression of podoplanin, LYVE1 and VEGFR3