Gene interactions and pathways from curated databases and text-mining

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PTGS2 — PTHLH

Text-mined interactions from Literome

Yoshida et al., J Clin Endocrinol Metab 2001 (Arthritis, Rheumatoid) : The IL-1alpha induced PTHrP production was inhibited by PG H synthetase ( Cox ) inhibitors, indomethacin, and also by Cox-2 inhibitor, NS398
Saito et al., Cancer Sci 2007 (Cachexia...) : These results demonstrate that production of PTHrP and IL-6 largely depends on the microenvironments in which tumors are developed or metastasized and that up-regulation of COX-2 in a necrobiotic environment leads to PTHrP production, thereby causing cachectic syndromes