Gene interactions and pathways from curated databases and text-mining

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PLD1 — PTH

Text-mined interactions from Literome

Singh et al., J Bone Miner Res 2003 : Regulation of parathyroid hormone stimulated phospholipase D in UMR-106 cells by calcium, MAP kinase, and small G proteins ... PTH activated p42/p44 MAP kinase, and the effects of PTH, PDBu, and ionomycin on PLD , but not on calcium influx, were prevented by the MEK inhibitors PD98059 and U0126 ... Small G proteins were shown to be involved in the effects of PTH , PDBu, and ionomycin on PLD
Radeff et al., Cell Signal 2004 (Bone Resorption) : Role of protein kinase A, phospholipase C and phospholipase D in parathyroid hormone receptor regulation of protein kinase Calpha and interleukin-6 in UMR-106 osteoblastic cells
Radeff et al., J Bone Miner Res 2004 : Diacylglycerol ( DAG ) generation from phospholipase D ( PLD ) is one pathway of PKC activation, and PTH mediated PLD activity is dependent on small G-proteins of the Rho family
Singh et al., Endocrinology 2005 : In the current study, we investigated the role of heterotrimeric G proteins in mediating PTH stimulated PLD activity in UMR-106 osteoblastic cells
Garrido et al., Mol Endocrinol 2009 : Role of phospholipase D in parathyroid hormone type 1 receptor signaling and trafficking ... PTH ( 1-34 ) increased total PLD activity by 3-fold in CHO-R3 cells and by 2-fold in ROS cells ... However, only WT-PLD2 expression increased PTH dependent PLD activity in ROS cells
Singh et al., Endocrinology 1999 : The results suggest that in the UMR-106 cell line PTH can stimulate activation of PLD by a mechanism other than through protein kinase C
Friedman et al., Endocrinology 1999 : PTH did, however, activate phospholipase D with attendant formation of diacylglycerol in distal cells