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IL1B — PTHLH
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Tsai et al., Calcif Tissue Int 2000
:
Interleukin-1beta upregulates
PTHrP-mRNA expression and protein production and decreases TGF-beta in normal human osteoblast-like cells ... Using a quantitative PCR-assay following reverse transcription of RNA, in situ hybridization, and a two-site immunofluorometric assay for PTHrP, we demonstrate that
IL-1beta in a dose- and time dependent manner
increases PTHrP-mRNA expression and PTHrP-protein secretion
Uemura et al., Jpn J Cancer Res 2000
(Carcinoma, Squamous Cell...) :
TNF-alpha or
IL-1beta induced both G-CSF and
PTHrP production in the conditioned medium
Funk et al., J Clin Invest 1993
:
Murine TNF-alpha and human
IL-1 beta , cytokines that mediate many of the effects of LPS, also
increased splenic
PTHrP mRNA levels ... LPS-resistant C3H/HeJ mice, which produce minimal amounts of TNF and IL-1 in response to LPS, were resistant to LPS induction of splenic PTHrP mRNA, while TNF-alpha and
IL-1 beta readily
increased PTHrP mRNA levels in C3H/HeJ mice
Casey et al., J Clin Endocrinol Metab 1993
:
17 beta-Estradiol ( E2 ),
interleukin-1 beta (IL-1 beta) , tumor necrosis factor-alpha (TNF alpha), endothelin-1 (ET-1), transforming growth factor-beta 1 ( TGF beta 1 ), and serum
stimulated PTH-rP production ( evaluated by immunoassay of PTH-rP in the culture medium ) by these cells
Funk et al., J Clin Invest 1998
(Arthritis, Rheumatoid...) :
TNF-alpha and
IL-1beta stimulated PTHrP expression in synoviocytes, while dexamethasone and interferon-gamma, agents with some therapeutic efficacy in the treatment of RA,
inhibited PTHrP release