◀ Back to TAT

PTK2 — TAT

Text-mined interactions from Literome

Rasheed et al., Journal of translational medicine 2009 (HIV Infections...) : Further, HIV-Tat can activate protein-tyrosine-kinase ( PTK-activity ) of the vascular endothelial growth factor receptor involved in stimulating angiogenic processes
Milani et al., AIDS 1998 : HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells ... Extracellular Tat induced a rapid increase of p125FAK tyrosine phosphorylation and p125FAK associated PI 3-K activity ... By using recombinant mutated Tat proteins, it was found that deletion of amino acids 73-86 encoded by the second exon of the tat gene resulted in a significant decrease of the ability of Tat to induce p125FAK tyrosine phosphorylation ... Paradoxically, mutations in the basic region encoded by the first exon of tat, which is essential for nuclear localization and HIV-1 LTR transactivation, increased the ability of Tat to stimulate p125FAK tyrosine phosphorylation ... Whereas the first event required intracellular Tat, the increased p125FAK phosphorylation was strictly dependent upon extracellular Tat