Gene interactions and pathways from curated databases and text-mining

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CSF1 — PTPN11

Text-mined interactions from Literome

Jack et al., Blood 2009 (MAP Kinase Signaling System) : SHP2 inhibition reduced ERK activation in G-CSF, but not M-CSF , and reduced colony forming unit-granulocytes, underscoring divergent pathways to ERK activation
Zhang et al., Blood 2011 (MAP Kinase Signaling System) : We previously found that G-CSF induces SHP2 tyrosine phosphorylation and that chemical inhibition of SHP1/SHP2 reduces CFU-G and prevents G-CSF but not M-CSF activation of ERK