Gene interactions and pathways from curated databases and text-mining

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EGFR — PTPRS

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Zhu et al., Wei Sheng Yan Jiu 2004 (Cleft Palate) : Down-regulation of Ptprs interfered with a cell signal pathway and down-regulation of Tn C inhibited the cell de-adhesion and expression of Egfr , then suppressed Egfr prevented the normal expression of MMPs that influenced the medial edge epithelium disruption and caused cleft palate
Xu et al., J Biol Chem 2005 : Co-expression of RPTP-kappa, but not other RPTPs , specifically reduced basal EGFR tyrosine phosphorylation