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CSF1 — RAC1
Text-mined interactions from Literome
Fukuda et al., J Bone Miner Res 2005
(Bone Resorption) :
Rac1 is critically
involved in
M-CSF receptor signaling and mediates survival signaling primarily through PI3K/Akt pathways ...
M-CSF rapidly
activated Rac1 , and the prosurvival effect of M-CSF for OCLs was abrogated by Rac1 ( DN ) overexpression ... Small guanosine triphosphatase ( GTPase )
Rac1 is critically
involved in
M-CSF receptor signaling and mediates survival signaling of osteoclasts primarily by modulating PI3K/Akt pathways
Kim et al., J Clin Invest 2006
(Bone Resorption) :
DEX specifically arrested
M-CSF activation of RhoA,
Rac , and Vav3, each of which regulate the osteoclast cytoskeleton
Sakai et al., Bone 2006
:
CSF-1 induced the association of Vav and
Rac and increased Rac 's GTPase activity ...
CSF-1 also
induced rapid translocation of
Rac to the periphery of spreading neonatal rat osteoclasts where it co-localized primarily with Vav3 and to a lesser extent with Vav1 ... Wortmannin, an inhibitor of PI3-K, blocked
CSF-1 induced
Rac translocation and prevented CSF-1 induced spreading and actin reorganization in osteoclasts
Yu et al., J Bone Miner Res 2007
:
We conclude that BCA3 regulates
CSF-1 dependent
Rac activation
Kim et al., Ann N Y Acad Sci 2007
:
Dexamethasone specifically arrests
M-CSF activation of RhoA,
Rac , and Vav3, each of which regulate the osteoclast cytoskeleton
Welliver et al., J Cell Sci 2011
:
Consistent with a role for these actin-rich structures in signal amplification, microscopic measures of Rac1 activity determined that disruption of actin polymerization by latrunculin B inhibited ruffling and the localized activation of
Rac1 in
response to
M-CSF