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JUN — RAC2

Text-mined interactions from Literome

Scita et al., Nature 1999 : The small guanine nucleotide ( GTP ) -binding protein Rac regulates mitogen induced cytoskeletal changes and c-Jun amino-terminal kinase (JNK) , and its activity is required for Ras mediated cell transformation
Pervaiz et al., Oncogene 2001 (Carcinoma...) : Rac is involved in actin polymerization, Jun kinase activation, and intracellular superoxide anion production, through distinct pathways in tumor cells
Habas et al., Genes Dev 2003 : Wnt/Fz activation of Rac is independent of Rho and mediates Wnt/Fz activation of Jun N-terminal kinase (JNK)
Honda et al., Genes Cells 2003 : Cdc42, and presumably Rac , activated in this way, induced the activation of c-Jun N-terminal kinase (JNK) , but not p38 mitogen activated protein ( MAP ) kinase or extracellular signal regulated kinase ( ERK )
Wroblewski et al., J Cell Sci 2003 (Neoplasm Invasiveness) : RhoA acted through activation of both NF-kappaB and AP-1, whereas Rac activated NF-kappaB but not AP-1
Boureux et al., J Cell Sci 2005 : Rac function required both a Jun N-terminal kinase (JNK) and a NADPH oxidase ( Nox ) pathway
Lee et al., Oncogene 2009 : In summary, Galpha(12) and Galpha(13) regulate the expression of the TGFbeta1 gene through an increase in Rho/Rac dependent AP-1 activity, implying that the G-protein coupled receptor ( GPCR ) -Galpha(12) pathway is involved in the TGFbeta1 mediated transdifferentiation process
Muthukrishnan et al., Gene 2009 : Over-expression of AP1 is sufficient to induce expression of a transiently transfected Rac2 promoter/luciferase plasmid, but not the endogenous Rac2 gene
Michiels et al., J Cell Biol 1997 : Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac dependent membrane ruffling and C-Jun NH2-terminal kinase activation
Li et al., J Biol Chem 1998 : Fibroblast transformation by Fps/Fes tyrosine kinases requires Ras, Rac , and Cdc42 and induces extracellular signal regulated and c-Jun N-terminal kinase activation ... Ras controls the activation of extracellular signal regulated kinases ( ERKs ), while Rac and Cdc42 regulate the c-Jun N-terminal kinases (JNKs)
Malliri et al., J Cell Biol 1998 : Our data establish a novel link between AP-1 activity and EGFR activation of Rac and Rho, which in turn mediate the actin cytoskeletal rearrangements required for cell motility and invasion