Gene interactions and pathways from curated databases and text-mining

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KRT8 — RAF1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of CFLAR-KRT18-KRT8-RAF1 → FAS (increases) Gilbert et al., Mol Cell Biol 2004*
    Evidence: c-Flip, along with Raf-1, is part of a K8/K18-immunoisolated complex from wild-type hepatocytes, and Fas stimulation leads to further c-Flip and Raf-1 recruitment in the complex.
  • OpenBEL Selventa BEL large corpus: Complex of KRT8-RAF1 → RAF1 (decreases, KRT8/RAF1 Activity) Ku et al., J Cell Biol 2004*
    Evidence: title := "Raf-1 activation disrupts its binding to keratins during cell stress." Raf activation during oxidative and toxin exposure in cultured cells and animals disrupt keratin-Raf association in a phosphorylation-dependent manner.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *