Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of CFLAR-KRT18-KRT8-RAF1
→
FAS
(increases)
Gilbert et al., Mol Cell Biol 2004* Evidence: c-Flip, along with Raf-1, is part of a K8/K18-immunoisolated complex from wild-type hepatocytes, and Fas stimulation leads to further c-Flip and Raf-1 recruitment in the complex.
OpenBEL Selventa BEL large corpus:
Complex of KRT8-RAF1
→
RAF1
(decreases, KRT8/RAF1 Activity)
Ku et al., J Cell Biol 2004* Evidence: title := "Raf-1 activation disrupts its binding to keratins during cell stress." Raf activation during oxidative and toxin exposure in cultured cells and animals disrupt keratin-Raf association in a phosphorylation-dependent manner.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *