Gene interactions and pathways from curated databases and text-mining

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MRE11A — RAPGEF4

Text-mined interactions from Literome

Aivatiadou et al., Mol Reprod Dev 2009 : cAMP-Epac2 mediated activation of Rap1 in developing male germ cells : RA-RhoGAP as a possible direct down-stream effector
Tsalkova et al., Assay Drug Dev Technol 2011 : Our in vitro analyses using purified full-length Epac2 and Rap1 suggest that sulfonylureas are not able to directly bind to Epac2, nor are they capable of triggering Epac2 dependent Rap1 activation