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CSF1 — RELA
Text-mined interactions from Literome
Rogler et al., Scand J Gastroenterol 2001
(Colitis, Ulcerative...) :
The induction of IL-8,
M-CSF and GM-CSF, but not of IL-6 secretion, is
mediated mainly by
NF-kappaB activation
Sugatani et al., J Cell Biochem 2003
:
Moreover, activin A enhanced RANKL- and
M-CSF stimulated nuclear translocation of
NFkappaB
Kwak et al., Biochem Pharmacol 2004
(Bone Resorption) :
M-CSF and RANKL
activate the ERK, Akt, and
NF-kappaB signal transduction pathways, and SCOH suppressed this activation
Oster et al., Blood 1992
:
However, the action of IL-3 on synthesis of IL-1 beta mRNA differs from that of other CSFs : While GM-CSF and
M-CSF induce binding activity of the
nuclear factor (NF) kappa B , IL-3 treatment of MNP has no profound effect on NF kappa B binding to DNA
Hohensinner et al., Journal of thrombosis and haemostasis : JTH 2007
:
To determine a possible
role of
nuclear factor kappaB (NF-kappaB) and activating protein 1 (AP-1) in
M-CSF regulation, blockers to both pathways and an adenovirus overexpressing a dominant negative ( dn ) form of IkappaB kinase 2 (IKK2) were used
Bonfield et al., J Immunol 2008
:
Taken together, these data suggest that M-CSF is an important mediator of alveolar macrophage homeostasis, and that transcriptional control of
M-CSF production is
regulated by
NF-kappaB and PPARgamma
Brach et al., Pathobiology 1991
:
The results suggest that
M-CSF induction of M-CSF
involves G proteins, PKC and
NF kappa B
Hong et al., J Immunol 1997
:
These results indicate that the generation of H2O2 and activation of
NF-kappaB by TGF-beta1 are
required for the induction of
M-CSF gene transcription