Gene interactions and pathways from curated databases and text-mining

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CCND1 — RENBP

Text-mined interactions from Literome

Guh et al., Am J Kidney Dis 2001 : We found that AGE increased cyclin D1 expression and cyclin dependent kinase (cdk)4 activity while decreasing p21 ( WAF1/CIP1 ) expression ... In addition, STAT5 decoy ODN reversed AGE induced cell-cycle dependent cellular proliferation and cyclin D1 protein expression
Chen et al., Translational research : the journal of laboratory and clinical medicine 2007 : AGE also increased tyrosine phosphorylation of Hsp70, cyclin E, and cyclin D1 ( to a lesser extent ) while increasing Hsp70 protein interactions with STAT1, STAT3, STAT5b, cyclin D1, and cyclin E. AGE induced tyrosine phosphorylation of Hsp70 and cyclin E ( but not cyclin D1 ) was attenuated by AG-490 ... AGE induced mitogenesis, cyclin D1 , and cyclin E were attenuated by Hsp70 antisense oligodeoxynucleotide and 2-aminopurine ( an Hsp70 inhibitor )