Gene interactions and pathways from curated databases and text-mining

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BMP7 — RGMA

Text-mined interactions from Literome

Babitt et al., J Biol Chem 2005 : We show that RGMa enhances BMP , but not TGF-beta, signals in a ligand dependent manner in cell culture ... RGMa mediates BMP signaling through the classical BMP signaling pathway involving Smad1, 5, and 8, and it up-regulates endogenous inhibitor of differentiation ( Id1 ) protein, an important downstream target of BMP signals
Xia et al., J Biol Chem 2007 : Furthermore, in BmpRII-null pulmonary artery smooth muscle cells, BMP2 and BMP4 signaling was reduced by inhibition of endogenous RGMa expression, and RGMa mediated BMP signaling required ActRIIA expression
Halbrooks et al., Journal of molecular signaling 2007 : Here, we investigate whether RGMa , RGMb, and RGMc play required roles in BMP and TGFbeta signaling in the mouse myoblast C2C12 cell line