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RGMA — RHOA
Text-mined interactions from Literome
Conrad et al., J Biol Chem 2007
:
Neogenin-RGMa signaling at the growth cone is bone morphogenetic protein independent and
involves RhoA , ROCK, and PKC ... In contrast to DRG cultures from neogenin-/- mice, in which no
RGMa mediated growth cone collapse and activation of
RhoA occurred, treatment of wild type DRG neurites with soluble RGMa led to a marked activation of RhoA within 3 min followed by collapse, but left Rac1 and Cdc42 unaffected
Schaffar et al., J Neurochem 2008
:
Binding of
RGM A to Neogenin
induces activation of the small GTPase
RhoA and of its effector Rho-kinase by an unknown mechanism
Hata et al., J Cell Biol 2009
:
RGMa binding to its receptor neogenin
induces RhoA activation, leading to inhibitory/repulsive behavior and collapse of the neuronal growth cone ... Focal adhesion kinase ( FAK ) is involved in
RGMa induced tyrosine phosphorylation of LARG as well as
RhoA activation