Gene interactions and pathways from curated databases and text-mining

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RGMA — RHOA

Text-mined interactions from Literome

Conrad et al., J Biol Chem 2007 : Neogenin-RGMa signaling at the growth cone is bone morphogenetic protein independent and involves RhoA , ROCK, and PKC ... In contrast to DRG cultures from neogenin-/- mice, in which no RGMa mediated growth cone collapse and activation of RhoA occurred, treatment of wild type DRG neurites with soluble RGMa led to a marked activation of RhoA within 3 min followed by collapse, but left Rac1 and Cdc42 unaffected
Schaffar et al., J Neurochem 2008 : Binding of RGM A to Neogenin induces activation of the small GTPase RhoA and of its effector Rho-kinase by an unknown mechanism
Hata et al., J Cell Biol 2009 : RGMa binding to its receptor neogenin induces RhoA activation, leading to inhibitory/repulsive behavior and collapse of the neuronal growth cone ... Focal adhesion kinase ( FAK ) is involved in RGMa induced tyrosine phosphorylation of LARG as well as RhoA activation