Kabuyama et al., Mol Cell Proteomics 2006
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Subsequent analysis demonstrated that RhoA enhances post-translational modification of PTP1B , inactivates phosphotyrosine phosphatase activity, and up-regulates tyrosine phosphorylation of p130Cas, a key mediator of focal adhesion turnover and cell migration
Burdisso et al., J Cell Sci 2013
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Pull-down and FRET analysis also showed that PTP1B is required for efficient integrin dependent downregulation of RhoA and upregulation of Rac1 during spreading