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PAF1 — RNASE3

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Turner et al., Br J Pharmacol 2000 : PAF increased the levels of eosinophil cationic protein (ECP) and kinin detected in the lavage samples, compared with a saline control
Simon et al., J Immunol 2000 (Eosinophilia) : In a model of eosinophil degranulation, we show that eosinophils release ECP upon short-term GM-CSF priming and stimulation with either platelet activating factor (PAF) or the anaphylatoxin C5a, but not eotaxin
Turner et al., Eur Respir J 1994 : Effects of PAF , FMLP and opsonized zymosan on the release of ECP , elastase and superoxide from human granulocytes ... Since eosinophils and eosinophil cationic proteins are thought to play an important role in the pathophysiology of asthma, we have examined the hypothesis that PAF may also stimulate eosinophil cationic protein (ECP) release from human granulocytes
Kawashima et al., Int Arch Allergy Immunol 1994 (Asthma) : Calcium ionophore A23187 caused both LTC4 and ECP release from human eosinophils, whereas PAF and FMLP induced only ECP release from the eosinophils ... Pemirolast ( 10 ( -6 ) to 10 ( -3 ) M ) inhibited A23187 induced LTC4 release from the eosinophils in a dose dependent fashion with 77 % inhibition at 10 ( -3 ) M. Pemirolast ( 10 ( -5 ) to 10 ( -3 ) M ) inhibited A23187 induced ECP release from the eosinophils in a dose dependent fashion with 42 % inhibition at 10 ( -3 ) M. Pemirolast ( 10 ( -4 ) and 10 ( -3 ) M ) also inhibited PAF induced and FMLP induced ECP release from the eosinophils
Eda et al., Ann Allergy 1993 : Loratadine, however, had no effect on PAF induced ECP release
Agrawal et al., Inflammation 1997 (Asthma...) : DP-1904 in two different concentrations, 10 microM and 100 microM, significantly attenuated the release of ECP in response to PAF or IgG