Gene interactions and pathways from curated databases and text-mining

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ADCY3 — RPIA

Text-mined interactions from Literome

Cushing et al., Am J Physiol 1991 : In an endothelium-free membrane preparation, ADO, CAD, and R-PIA all stimulated adenylate cyclase activity in a concentration dependent manner, and these responses were blocked by 8-SPT
Olianas et al., Life Sci 1990 : R-PIA inhibited both basal and FSK stimulated adenylate cyclase activity
Ramkumar et al., Mol Pharmacol 1990 : Adenosine receptor agonists [(R)-PIA , NECA, and ( S ) -PIA ] inhibited isoproterenol stimulated adenylate cyclase activity in DDT1 MF-2 cell membranes with IC50 values of 62, 538, and 750 nM, respectively
Hu et al., Pharmacol Toxicol 1987 : However, at 1 mumol/l neither Bay K 8644 nor nifedipine significantly attenuated cyclic AMP accumulation in rat hippocampi or the R-PIA mediated adenylate cyclase inhibition
Abbracchio et al., Pharmacol Res Commun 1987 : To test whether adenosine modulation of the dopaminergic function could be, at least in part, due to an interaction at the level of the adenylate cyclase complex, we studied the effects of the adenosine analog R-Phenyl-isopropil-adenosine (R-PIA) on basal and dopamine-sensitive adenylate cyclase in rat striatum ... Conversely, after subchronic treatment with neuroleptics such as haloperidol or sulpiride, upregulation of 3H-Spiroperidol binding in striatum was not associated with changes of R-PIA dependent adenylate cyclase in this area