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RPS6KB1 — TP53

Text-mined interactions from Literome

Lai et al., EMBO J 2010 : The activated S6K1 forms a tighter complex with Mdm2, inhibits Mdm2 mediated p53 ubiquitination, and promotes p53 induction, in addition to phosphorylating Mdm2 on S163
Jia et al., Cell Death Differ 2013 : IKK-ß and p85 S6K1 contributed to H ( 2 ) O ( 2 ) -induced phosphorylation of Mdm2 ( S166 ) and p53 accumulation
Xiong et al., Journal of the American Heart Association 2013 : The activation of p66Shc but not p53 by Arg-II was dependent on extracellular signal regulated kinases ( ERKs ) and sequential activation of 40S ribosomal protein S6 kinase 1 (S6K1)-c-Jun N-terminal kinases (JNKs)