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ANXA6 — RPTOR

Text-mined interactions from Literome

Gibbons et al., Semin Oncol 2009 (Neoplasms) : Activated mTORC1 regulates protein synthesis by directly phosphorylating 4E-binding protein 1 (4E-BP1) and p70S6K ( S6K ), translation initiation factors that are important to cap dependent mRNA translation, which increases the level of many proteins that are needed for cell cycle progression, proliferation, angiogenesis, and survival pathways
Sini et al., Autophagy 2010 (Neoplasms) : mTORC1 activates p70S6K , which in turn phosphorylates the ribosomal protein S6 and 4E-BP1, both involved in protein translation
Shen et al., International journal of clinical and experimental pathology 2010 (Carcinoma, Endometrioid...) : mTORC1 and mTORC2 phosphorylatively regulate their respective downstream effectors p70S6K/4EBP1 , and Akt
Li et al., Am J Physiol Cell Physiol 2011 (MAP Kinase Signaling System) : Here, we demonstrate that the inhibition of mTORC1 by rapamycin ( mTORC1 inhibitor ), torin1 ( both mTORC1 and mTORC2 inhibitor ) or short hairpin RNA mediated knockdown of mTOR, regulatory associated protein of mTOR ( RAPTOR ), and p70 S6 kinase (p70S6K) increased basal NT release via upregulating NT gene expression in BON cells
Marzec et al., PloS one 2011 (Lymphoma, T-Cell, Cutaneous) : mTORC1 activates p70S6kinase 1 (p70S6K1) and inhibits 4E-binding protein 1 (4E-BP1)
Ciechomska et al., Oncogene 2013 (Brain Neoplasms...) : Decrease of phosphorylation of 4E-BP1, p70S6K1 and its downstream target S6 ribosomal protein demonstrate inhibition of mTOR signaling by CsA
Dennis et al., J Biol Chem 2013 : Together, these findings support the conclusion that, in the absence of 4E-BP proteins, mTORC1 mediated phosphorylation of p70S6K1 is elevated by a reduction in competition between the two substrates for interaction with raptor