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EPHB2 — SETD2
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Minet et al., FEBS Lett 2000
:
In this report, we investigated the activation of
extracellular regulated kinases (ERK) in hypoxia and their
involvement in
HIF-1 activation
Mottet et al., J Cell Physiol 2003
(Calcium Signaling) :
Role of
ERK and calcium in the hypoxia induced activation of
HIF-1
Schweppe et al., J Biol Chem 2006
(Anoxia) :
Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for
HIF-1 in
ERK5 mediated responses
Sutton et al., Oncogene 2007
:
Conversely, treatment of tumour cells with the MEK1/2 inhibitors PD98059 or U0216, or expression of a dominant negative form of
ERK1 blocked
HIF-1 activation in hypoxia without affecting HIF-1alpha induction, localization or binding of HIF-1beta
Zhang et al., Cancer Lett 2011
(Anoxia...) :
Furthermore, the expression of
HIF-1a induced by SCF is not
dependent on the oxygen level, but rather on both the PI3K/Akt and
Ras/MEK/ERK signaling pathways
Luwor et al., Cancer Lett 2011
(Carcinoma, Squamous Cell...) :
Compared with corresponding control cells, A431-Ras cells exhibited marked resistance to the EGFR inhibitors cetuximab and gefitinib, reducing inhibition of Akt and
Erk phosphorylation,
inhibition of
HIF-1a expression and transcriptional activity, and antitumor effects in vitro and in vivo
Liu et al., PloS one 2011
(Neovascularization, Pathologic) :
The AKT and
ERK inhibitors, LY294002 and U0126,
suppressed HIF-1a and VEGF expression and angiogenesis
Du et al., PloS one 2011
(Breast Neoplasms) :
PI3K and
ERK induced Rac1 activation
mediates hypoxia induced
HIF-1a expression in MCF-7 breast cancer cells
Wu et al., J Pathol 2011
(Endometriosis) :
In contrast, forced expression of DUSP2 under hypoxia abolishes
HIF-1a induced
ERK phosphorylation and COX-2 expression
Wu et al., PloS one 2012
:
Inhibition of ERK1/2 using UO126 or PD98059 reduced but did not abolish OA-NO ( 2 ) -induced HIF-1a upregulation, suggesting that OA-NO ( 2 ) /HO-1 initiated
HIF-1a induction is partially
dependent on
ERK1/2 activity
Yang et al., Oncogene 2013
(Melanoma...) :
In conclusion, our findings provide evidence that GAB2 is a novel regulator of tumor angiogenesis in NRAS-driven melanoma through regulation of
HIF-1a and VEGF expressions
mediated by
RAS-RAF-MEK-ERK signaling
Paweł et al., Lipids 2013
(Leiomyoma...) :
Additionally, in uterine leiomyomas we found relevant activation of both PTEN and
MAPK(ERK1/2) signaling pathways with only a minor change in AKT activity and relatively absent
HIF-1a/AMPK activation
Fu et al., PloS one 2013
:
BBR also downregulated
HIF-1a and VEGF expression and
inhibited Akt and
ERK phosphorylation
Shin et al., PloS one 2013
(Neovascularization, Pathologic...) :
Mechanistically, MEL specifically
inhibited the EGF induced
HIF-1a expression by suppressing the phosphorylation of
ERK , mTOR and p70S6K